High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

doi:10.1371/journal.pgen.1000696

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Article

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

PLoS genetics - 1 Oct 2009

Barcellos Lisa F, May Suzanne L, Ramsay Patricia P, Quach Hong L, Lane Julie A, Nititham Joanne, Noble Janelle A, Taylor Kimberly E, Quach Diana L, Chung Sharon A, Kelly Jennifer A, Moser Kathy L, Behrens Timothy W, Seldin Michael F, Thomson Glenys, Harley John B, Gaffney Patrick M, Criswell Lindsey A

Abstract excerpt

A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked statistical power and genetic resolution to fully define MHC influences. We characterized 1,610 Caucasian SLE cases and 1,470 parents for 1,974 MHC SNPs, the highly polymorphic HLA-DRB1 locus, and a panel of ancestry...

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Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Lupus Erythematosus, Systemic

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PMID: 19851445
DOI: 10.1371/journal.pgen.1000696
PMCID: PMC2758598

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