Article
Exome-wide association study identifies four novel loci for systemic lupus erythematosus in Han Chinese population.
Annals of the rheumatic diseases - 1 Mar 2018
Wen Leilei, Zhu Caihong, Zhu Zhengwei, Yang Chao, Zheng Xiaodong, Liu Lu, Zuo Xianbo, Sheng Yujun, Tang Huayang, Liang Bo, Zhou Yi, Li Pan, Zhu Jun, Ding Yantao, Chen Gang, Gao Jinping, Tang Lili, Cheng Yuyan, Sun Jingying, Elango Tamilselvi, Kafle Anjana, Yu Ruixing, Xue Ke, Zhang Yaohua, Li Feng, Li Zhanguo, Guo Jianping, Zhang Xuan, Zhou Chen, Tang Yuanjia, Shen Nan, Wang Meng, Yu Xueqing, Liu Shengxiu, Fan Xing, Gao Min, Xiao Fengli, Wang Peiguang, Wang Zaixing, Zhang Anping, Zhou Fusheng, Sun Liangdan, Yang Sen, Xu Jinhua, Yin Xianyong, Cui Yong, Zhang Xuejun
Abstract excerpt
OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of considerable genetic predisposition. Genome-wide association studies have identified tens of common variants for SLE. However, the majority of them reside in non-coding sequences. The contributions of coding variants have not yet been systematically evaluated. METHODS: We performed a large-scale exome-wide study in 5004 SLE cases...
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