Article
Recent advances in understanding the genetic basis of systemic lupus erythematosus.
Seminars in immunopathology - 1 Jan 2022
Ha Eunji, Bae Sang-Cheol, Kim Kwangwoo
Abstract excerpt
Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly 180 reported susceptibility loci that have been identified mostly by genome-wide association studies (GWASs) and account for approximately 30% of genetic heritability. A vast majority of risk variants reside in non-coding regions, which...
Topics
- Epigenesis, Genetic
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lupus Erythematosus, Systemic
- Polymorphism, Single Nucleotide