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Article

Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population.

Science China. Life sciences - 1 May 2025

Zhou Cong, Gong Tingting, Li Shuhang, Jin Li, Fan Shaohua

Abstract excerpt

Human leukocyte antigen (HLA) genes in the major histocompatibility complex (MHC) region are crucial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing (SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing (LRS) and SRS...

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PMID: 39821835
DOI: 10.1007/s11427-024-2742-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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