Article
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.
Nature genetics - 1 Jul 2016
Zhou Fusheng, Cao Hongzhi, Zuo Xianbo, Zhang Tao, Zhang Xiaoguang, Liu Xiaomin, Xu Ricong, Chen Gang, Zhang Yuanwei, Zheng Xiaodong, Jin Xin, Gao Jinping, Mei Junpu, Sheng Yujun, Li Qibin, Liang Bo, Shen Juan, Shen Changbing, Jiang Hui, Zhu Caihong, Fan Xing, Xu Fengping, Yue Min, Yin Xianyong, Ye Chen, Zhang Cuicui, Liu Xiao, Yu Liang, Wu Jinghua, Chen Mengyun, Zhuang Xuehan, Tang Lili, Shao Haojing, Wu Longmao, Li Jian, Xu Yu, Zhang Yijie, Zhao Suli, Wang Yu, Li Ge, Xu Hanshi, Zeng Lei, Wang Jianan, Bai Mingzhou, Chen Yanling, Chen Wei, Kang Tian, Wu Yanyan, Xu Xun, Zhu Zhengwei, Cui Yong, Wang Zaixing, Yang Chunjun, Wang Peiguang, Xiang Leihong, Chen Xiang, Zhang Anping, Gao Xinghua, Zhang Furen, Xu Jinhua, Zheng Min, Zheng Jie, Zhang Jianzhong, Yu Xueqing, Li Yingrui, Yang Sen, Yang Huanming, Wang Jian, Liu Jianjun, Hammarström Lennart, Sun Liangdan, Wang Jun, Zhang Xuejun
Abstract excerpt
The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC...
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