Article

Targeting glucocorticoid signalling in dendritic cells for glioblastoma treatment

2026-08-12

Abstract excerpt

Glioblastoma (GBM) remains a devastating disease with few meaningful therapeutic advances over the past three decades. Dendritic cell (DC) vaccination is a promising immunotherapeutic strategy for GBM, but its efficacy is limited by the clinical use of dexamethasone to control cerebral oedema and associated symptoms. Here we show that steroid signalling is a central regulator of DC dysfunction in GBM. Through targ...

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Literature Corpus work: aa7627ed-bf64-5542-ac45-8d8a26633631
DOI: 10.64898/2026.08.07.742730

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