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Article

Dexamethasone-mediated oncogenicity in vitro and in an animal model of glioblastoma

12 Jan 2018

Abstract excerpt

OBJECTIVEDexamethasone, a known regulator of mesenchymal programming in glioblastoma (GBM), is routinely used to manage edema in GBM patients. Dexamethasone also activates the expression of genes, such as CEBPB, in GBM stem cells (GSCs). However, the drug's impact on invasion, proliferation, and angiogenesis in GBM remains unclear. To determine whether dexamethasone induces invasion, proliferation, and...

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PMID: 29328002
DOI: 10.3171/2017.7.jns17668

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