Article

Glucocorticoid receptor activation reprograms NK cells to drive AREG-mediated immunosuppression in skin cancer

2023-09-16

Abstract excerpt

<h4>Summary</h4> Natural killer (NK) cells are potent mediators of anti-tumor immunity, yet their functions are frequently subverted by tumor microenvironment-driven immunosuppression. Here, we dissect the molecular mechanisms underlying NK cell dysfunction in cutaneous malignancies and identify a paradoxical cytokine shift in tumor-associated NK cells-reduced production of IFN-γ and TNF-α alongside elevated amph...

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Literature Corpus work: 180e733a-143b-5bdf-a186-8b5d916b1a0f
DOI: 10.1101/2023.09.13.557530

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