Glucocorticoid receptor and RUNX transcription factors cooperatively drive CD8 T cell dysfunction in human cancer

Abstract excerpt

Glucocorticoids (GCs) are potent modulators of immune responses; however, the mechanisms by which GCs regulate gene expression in human CD8 T cells remain incompletely defined. Here, we delineate how physiological cortisol signalling shapes the transcriptional and chromatin landscapes of primary human CD8 T cells. We identify a substantial cohort of GC-responsive genes that are co-regulated through the cooperative...

Topics

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• Cytokine Signaling Pathways and Interactions
• Estrogen and related hormone effects
• HER2/EGFR in Cancer Research
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Lymphoma Diagnosis and Treatment
• NF-κB Signaling Pathways
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

7520dc8b-fd26-5540-9fd9-c15016571601

DOI

10.1101/2025.04.30.651472