Article

Protective effects of testosterone replacement therapy on brain tumor outcomes: the Mayo Clinic Experience

2026-08-10

Abstract excerpt

<h4>Background</h4> Biological sex and endocrine signaling influence cancer biology, immune response, and therapeutic outcomes. Recent evidence suggests that testosterone signaling may exert brain-context-dependent protective effects in glioblastoma through the hypothalamic-pituitary-adrenal axis, reduced glucocorticoid-mediated immune suppression, and altered tumor-immune interactions. We assessed whether testos...

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Literature Corpus work: 693276a4-6abf-55a5-86d5-29d8569ba2c4
DOI: 10.64898/2026.08.07.26359970

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