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Article

Dysfunctional dendritic cells limit antigen-specific T cell response in glioma.

Neuro-oncology - 14 Feb 2023

Friedrich Mirco, Hahn Markus, Michel Julius, Sankowski Roman, Kilian Michael, Kehl Niklas, Günter Manina, Bunse Theresa, Pusch Stefan, von Deimling Andreas, Wick Wolfgang, Autenrieth Stella E, Prinz Marco, Platten Michael, Bunse Lukas

Abstract excerpt

BACKGROUND: Dendritic cells (DC), the most potent professional antigen presenting cells capable of effective cross-presentation, have been demonstrated to license T helper cells to induce antitumor immunity in solid tumors. Specific DC subtypes are recruited to the injured brain by microglial chemokines, locally adapting to distinct transcriptional profiles. In isocitrate dehydrogenase (IDH) type 1 mutant...

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Identifiers

PMID: 35609569
DOI: 10.1093/neuonc/noac138
PMCID: PMC9925697

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