Article

Convection-enhanced delivery of dexamethasone in glioma suppresses myeloid inflammation while avoiding systemic toxicities

2025-09-26

Abstract excerpt

Dexamethasone is widely used to control cerebral edema and inflammation in glioblastoma, but its benefits are limited by systemic toxicities and adverse prognostic associations. We evaluated local administration of dexamethasone via convection-enhanced delivery (CED) to maximize intratumoral anti-inflammatory effects by increasing local corticosteroid exposure while minimizing systemic exposure. In two glioma mous...

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Identifiers and source

Literature Corpus work: f3dcdc3d-6369-5229-a11e-62d0e405f538
DOI: 10.1101/2025.09.24.677899

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