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Article

Glucocorticoids induce a phagocytic C1Q+ macrophage phenotype primed for IFNγ-dependent CXCL9 secretion.

Scientific reports - 18 May 2026

Triebig Alexandra S, Maier Tanja, Schwarzlmueller Paul, Atici Sena, Kirmaier Martin E, Chortis Vasileios, Borges Kleiton S, Breault David T, Ribeiro Claudio, Gottschlich Adrian, Landwehr Laura-Sophie, Bechmann Nicole, Peitzsch Mirko, Paramasivam Nagarajan, Theurich Sebastian, Fröhling Stefan, Glimm Hanno, Hübschmann Daniel, Fassnacht Martin, Reincke Martin, Friedmann-Angeli Jose Pedro, Weigand Isabel, Kroiss Matthias

Abstract excerpt

Glucocorticoids are an emerging component of the tumor microenvironment and play a multifaceted role in modulating immune responses. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy characterized by systemic cortisol excess in ~ 60% of cases. Responses to immune checkpoint inhibitors (ICI) in patients with ACC are variable, and currently, no reliable biomarkers exist to predict therapeutic outcomes....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42151378
DOI: 10.1038/s41598-026-52733-y
PMCID: PMC13183869

Genes

CD163
CXCL9
CD4
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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