Article

An endogenous glucocorticoid-cytokine signaling circuit promotes CD8 <sup>+</sup> T cell dysfunction in the tumor microenvironment

2019-10-10

Abstract excerpt

Identifying signals in the tumor microenvironment (TME) that promote CD8 + T cell dysfunction can inform improved therapeutic approaches for cancer. Here, we identify that Nr3c1 , the gene encoding the glucocorticoid receptor (GR), is highly expressed in dysfunctional CD8 + tumor-infiltrating lymphocytes (TILs). The GR transactivates expression of multiple checkpoint receptors and loss of GR in CD8 + T cells l...

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Literature Corpus work: 71cb4e8f-173d-5384-8246-571b9a9707f7
DOI: 10.1101/799759

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