Article

Genome Editing With Targeted Deaminases

2016-07-28

Abstract excerpt

Precise genetic modifications are essential for biomedical research and gene therapy. Yet, traditional homology-directed genome editing is limited by the requirements for DNA cleavage, donor DNA template and the endogenous DNA break-repair machinery. Here we present programmable cytidine deaminases that enable site-specific cytidine to thymidine (C-to-T) genomic edits without the need for DNA cleavage. Our targete...

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Literature Corpus work: aa6f0520-4be1-5859-8756-27f265ad1ad1
DOI: 10.1101/066597

Open publication

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