Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases

Abstract excerpt

Abstract Base editing in nuclear DNA and mitochondrial DNA (mtDNA) is broadly useful for biomedical research, medicine, and biotechnology. Here, we present a base editing platform, termed zinc finger deaminases (ZFDs), composed of custom-designed zinc-finger DNA-binding proteins, the split interbacterial toxin deaminase DddA tox , and a uracil glycosylase inhibitor (UGI), which catalyze targeted C-to-T base...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CRISPR and Genetic Engineering
• Share to Cytomegalovirus and herpesvirus research
• Share to RNA regulation and disease