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Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes

4 Sept 2025

Abstract excerpt

Base editors create precise genomic edits by directing nucleobase deamination or removal without inducing double-stranded DNA breaks. However, a vast chemical space of other DNA modifications remains to be explored for genome editing. Here we harness the bacterial antiphage toxin DarT2 to append ADP-ribosyl moieties to DNA, unlocking distinct editing outcomes in bacteria versus eukaryotes. Fusing an attenuated...

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PMID: 40908325
DOI: 10.1038/s41587-025-02802-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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