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Article

CRISPR base editors: genome editing without double-stranded breaks

11 Jun 2018

Abstract excerpt

The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 adaptive immunity system has been harnessed for genome editing applications across eukaryotic species, but major drawbacks, such as the inefficiency of precise base editing and off-target activities, remain. A catalytically inactive Cas9 variant (dead Cas9, dCas9) has been fused to diverse functional domains for targeting genetic and...

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PMID: 29891532
DOI: 10.1042/bcj20170793

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