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Article

Mutational rescue of the activity of high-fidelity Cas9 enzymes.

Cell reports methods - 22 Apr 2024

Vos Pascal D, Gandadireja Andrianto P, Rossetti Giulia, Siira Stefan J, Mantegna Jessica L, Filipovska Aleksandra, Rackham Oliver

Abstract excerpt

Programmable DNA endonucleases derived from bacterial genetic defense systems, exemplified by CRISPR-Cas9, have made it significantly easier to perform genomic modifications in living cells. However, unprogrammed, off-target modifications can have serious consequences, as they often disrupt the function or regulation of non-targeted genes and compromise the safety of therapeutic gene editing applications....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38608689
DOI: 10.1016/j.crmeth.2024.100756
PMCID: PMC11046035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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