Article

A reversible KO model reveals therapeutic potentials of defective Tregs

2019-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Tregs must be activated to suppress immune responses, but the transcriptional program controlling Treg activation remains incompletely understood. We previously found that Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg activation and causes fatal autoimmunity in mice. Here, using a method that allows gene KO to be reversed in a Tamoxifen-dependent manner, we address...

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Literature Corpus work: aa4ac7ec-9918-5aa4-aad2-2fb71a4ebb39
DOI: 10.1101/770347

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