Article
In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice.
Nature communications - 3 Jun 2020
Li Yongqin, Chen Yuxin, Mao Shaoshuai, Kaundal Ravinder, Jing Zhengyu, Chen Qin, Wang Xinxin, Xia Jing, Liu Dahai, Sun Jianlong, Wang Haopeng, Chi Tian
Abstract excerpt
Mutations disrupting regulatory T (Treg) cell function can cause IPEX and IPEX-related disorders, but whether established disease can be reversed by correcting these mutations is unclear. Treg-specific deletion of the chromatin remodeling factor Brg1 impairs Treg cell activation and causes fatal autoimmunity in mice. Here, we show with a reversible knockout model that re-expression of Brg1, in conjunction with...
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