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Article

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.

Nature - 28 Jan 2016

Luo Chong T, Liao Will, Dadi Saida, Toure Ahmed, Li Ming O

Abstract excerpt

Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a pivotal role in maintaining immunological self-tolerance; yet, excessive Treg cell activities suppress anti-tumour immune responses. Compared to the resting Treg (rTreg) cell phenotype in secondary lymphoid organs, Treg cells in non-lymphoid tissues exhibit an activated Treg (aTreg) cell phenotype. However, the function of aTreg cells and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26789248
DOI: 10.1038/nature16486
PMCID: PMC4978705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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