Article

Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity

2025-07-26

Abstract excerpt

Reprogramming autoreactive CD4 + effector T (T eff ) cells into immunosuppressive regulatory T (T reg ) cells represents a promising strategy for treating established autoimmune diseases. However, the stability and function of such reprogrammed T regs under inflammatory conditions remain unclear. Here, we show that demethylation of core T reg identity genes in T eff cells yields lineage-stable Effector T cel...

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Literature Corpus work: ae1e78c6-ed1e-57b9-8a10-81109b72b1f3
DOI: 10.1101/2025.07.24.665398

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