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Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications

24 Feb 2021

Abstract excerpt

Regulatory Tcells (Treg) are essential components of peripheral immune homeostasis. Adoptive Treg cell therapy has shown efficacy in a variety of immune-mediated diseases in preclinical studies and is now moving from phase I/IIa to larger phase II studies aiming to demonstrate efficacy. However, hurdles such asin vivostability and efficacy remain to be addressed. Nevertheless, preclinical models have shown that...

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PMID: 33717052
DOI: 10.3389/fimmu.2020.611638

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