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Gata3 ZsG and Gata3 ZsG-fl: Novel murine Gata3 reporter alleles for identifying and studying Th2 cells and ILC2s in vivo.

Frontiers in immunology - 1 Jan 2022

Gurram Rama K, Wei Danping, Yu Qiao, Kamenyeva Olena, Chung Hyunwoo, Zheng Mingzhu, Butcher Matthew J, Kabat Juraj, Liu Chengyu, Khillan Jaspal S, Zhu Jinfang

Abstract excerpt

T helper-2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) play crucial roles during type 2 immune responses; the transcription factor GATA3 is essential for the differentiation and functions of these cell types. It has been demonstrated that GATA3 is critical for maintaining Th2 and ILC2 phenotype in vitro; GATA3 not only positively regulates type 2 lymphocyte-associated genes, it also negatively regulates...

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Identifiers

PMID: 36466899
DOI: 10.3389/fimmu.2022.975958
PMCID: PMC9709206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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