Article

Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunity

2021-04-29

Abstract excerpt

<h4>ABSTRACT</h4> The NR4A family of orphan nuclear receptors ( Nr4a1-3 ) plays redundant roles upstream of Foxp3 to establish and maintain Treg identity; deletion of multiple family members in the thymus results in Treg deficiency and a severe inflammatory disease. Consequently, it has been challenging to isolate the functions of this family in other immune cells. Here we take advantage of a competitive bone m...

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Literature Corpus work: efd323c3-f65b-5534-9ccd-c4a032269718
DOI: 10.1101/2021.04.28.441904

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