Article

Polygenic effect on accelerated tau pathology accumulation in Alzheimer’s disease: implications for patient selection in clinical trials

2021-11-02

Abstract excerpt

Progression of fibrillar tau is a key driver of dementia symptoms in Alzheimer’s disease (AD), but predictors of the rate of tau accumulation at patient-level are missing. Here we combined the to-date largest number of genetic risk variants of AD (n=85 lead SNPs) from recent GWAS to generate a polygenic score (PGS) predicting the rate of change in fibrillar tau. We found that a higher PGS was associated with highe...

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Literature Corpus work: aa362231-9a0b-5c1f-bf67-b5c2e237ebe2
DOI: 10.1101/2021.11.02.21265788

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