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Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.

Alzheimer's research & therapy - 25 Apr 2026

Cohen Celeste E, Fernandez Shane, Yaman Umran, Ehyaei Ahmad R, Kodosaki Eleftheria, Askarova Aydan, Porter Tenielle, O'Brien Eleanor, Maruff Paul, Nott Alexi, Hardy John A, Laws Simon M, A Salih Dervis, Shoai Maryam

Abstract excerpt

BACKGROUND: Recent trials in Alzheimer’s disease (AD) demonstrate encouraging outcomes. These trials target risk mechanisms identified through genetic analysis whilst directly aiming to reduce progression rates. Evidence from other neurodegenerative diseases suggests the genetics of progression is distinct from risk of disease. To expand these initial successes and improve clinical outcomes further we need to...

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Identifiers

PMID: 42035106
DOI: 10.1186/s13195-026-02036-1

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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