Article

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease

2023-06-05

Abstract excerpt

Alzheimer’s disease (AD) heritability is enriched in glial genes, but how and when cell-type-specific genetic risk contributes to AD remains unclear. Here, we derive cell-type-specific AD polygenic risk scores (ADPRS) from two extensively characterized datasets. In an autopsy dataset spanning all stages of AD (n=1,457), astrocytic (Ast) ADPRS was associated with both diffuse and neuritic Aβ plaques, while microgli...

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Literature Corpus work: 368d2894-e408-53b2-ab98-f8bca6afc57e
DOI: 10.1101/2023.06.01.23290850

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