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Article

A/T/N polygenic risk score for cognitive decline in old age

2019-11-12

Abstract excerpt

<h4>INTRODUCTION</h4> We developed a novel polygenic risk score (PRS) based on the A/T/N (amyloid plaques (A), phosphorylated tau tangles (T), and neurodegeneration (N)) framework and compared a PRS based on clinical AD diagnosis to assess which was a better predictor of cognitive decline. <h4>METHODS</h4> We used summary statistics from genome wide association studies of cerebrospinal fluid amyloid-β (Aβ 42 )...

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Literature Corpus work
506c4d85-b439-58bd-beec-009d8780f3a1
DOI
10.1101/838847
Open publication

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