Article

Polygenic Scores of Core-1 Alzheimer’s Disease Biomarkers Predict Early Cognitive and Pathological Change

2025-07-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Core-1 biomarkers, such as amyloid PET, capture the earliest biological changes leading to Alzheimer’s disease (AD). While APOE is a major genetic factor, the contribution of other variants to Core-1 biomarkers remains unclear. The goal of this study is to determine whether genetic regulators of Core-1 biomarker levels predict AD pathology better than genetic regulators of c...

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Literature Corpus work: 08fcb476-776e-51e0-884f-fa3a9e6c600e
DOI: 10.1101/2025.07.12.25331438

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