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Benchmarking Alzheimer's disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies.

Alzheimer's research & therapy - 6 Jan 2025

Bellou Eftychia, Kim Woori, Leonenko Ganna, Tao Feifei, Simmonds Emily, Wu Ying, Mattsson-Carlgren Niklas, Hansson Oskar, Nagle Michael W, Escott-Price Valentina

Abstract excerpt

BACKGROUND: The success of selecting high risk or early-stage Alzheimer's disease individuals for the delivery of clinical trials depends on the design and the appropriate recruitment of participants. Polygenic risk scores (PRS) show potential for identifying individuals at risk for Alzheimer's disease (AD). Our study comprehensively examines AD PRS utility using various methods and models. METHODS: We compared...

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Alzheimer Disease
Apolipoproteins E
Benchmarking
Cohort Studies
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Multifactorial Inheritance

Risk Assessment

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Open in PubMed Open full text

Identifiers

PMID: 39762974
DOI: 10.1186/s13195-024-01664-9
PMCID: PMC11702271

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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