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Article

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.

Neurology - 2 Aug 2016

Mormino Elizabeth C, Sperling Reisa A, Holmes Avram J, Buckner Randy L, De Jager Philip L, Smoller Jordan W, Sabuncu Mert R

Abstract excerpt

OBJECTIVE: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS: We computed polygenic risk scores (PGRS) using summary statistics from the International Genomics of Alzheimer's Project genome-wide association study of AD. Associations between PGRS and AD markers...

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Identifiers

PMID: 27385740
DOI: 10.1212/WNL.0000000000002922
PMCID: PMC4970660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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