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Immune Cell-Based Transcriptomic Mendelian Randomization and Colocalization Study on Type 1 Diabetes

2025-07-02

Abstract excerpt

<h4>Background</h4> Interventions to prevent type 1 diabetes (T1D), a disease requiring lifelong treatment, remain limited. We sought to identify novel therapeutic targets for T1D through Mendelian randomization and colocalization using immune cell-derived instruments. <h4>Methods</h4> We selected locally-acting genetic variants from 14 transcriptomic studies to instrument expression of 8,998 genes measured in i...

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Literature Corpus work
deaccd2e-c985-5b14-9c6f-96c78a07598e
DOI
10.1101/2025.07.01.25330014
Open publication

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Immune Cell-Based Transcriptomic Mendelian Randomization and Colocalization Study on Type 1 DiabetesDOI 10.1101/2025.07.01.25330014
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