Article

CRISPR activation and interference screens in primary human T cells decode cytokine regulation

2021-05-12

Abstract excerpt

The pathways that regulate cytokine responses in T cells are disrupted in autoimmunity, immune deficiencies, and cancer, and include immunotherapy targets. Systematic discovery of cytokine regulators requires both loss-of-function and gain-of-function studies, which have been challenging in primary human cells. We now have accomplished genome-wide pooled CRISPR activation (CRISPRa) and CRISPR interference (CRISPRi...

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Literature Corpus work: d95076f3-32f8-5871-8606-c293acc36c95
DOI: 10.1101/2021.05.11.443701

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