Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.

doi:10.1016/j.cell.2021.03.056

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Article

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.

Cell - 27 May 2021

Ota Mineto, Nagafuchi Yasuo, Hatano Hiroaki, Ishigaki Kazuyoshi, Terao Chikashi, Takeshima Yusuke, Yanaoka Haruyuki, Kobayashi Satomi, Okubo Mai, Shirai Harumi, Sugimori Yusuke, Maeda Junko, Nakano Masahiro, Yamada Saeko, Yoshida Ryochi, Tsuchiya Haruka, Tsuchida Yumi, Akizuki Shuji, Yoshifuji Hajime, Ohmura Koichiro, Mimori Tsuneyo, Yoshida Ken, Kurosaka Daitaro, Okada Masato, Setoguchi Keigo, Kaneko Hiroshi, Ban Nobuhiro, Yabuki Nami, Matsuki Kosuke, Mutoh Hironori, Oyama Sohei, Okazaki Makoto, Tsunoda Hiroyuki, Iwasaki Yukiko, Sumitomo Shuji, Shoda Hirofumi, Kochi Yuta, Okada Yukinori, Yamamoto Kazuhiko, Okamura Tomohisa, Fujio Keishi

Abstract excerpt

Genetic studies have revealed many variant loci that are associated with immune-mediated diseases. To elucidate the disease pathogenesis, it is essential to understand the function of these variants, especially under disease-associated conditions. Here, we performed a large-scale immune cell gene-expression analysis, together with whole-genome sequence analysis. Our dataset consists of 28 distinct immune cell...

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PMID: 33930287
DOI: 10.1016/j.cell.2021.03.056

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