Article

Individualized VDJ recombination predisposes the available Ig sequence space

2021-04-19

Abstract excerpt

The process of recombination between variable (V), diversity (D), and joining (J) immunoglobulin (Ig) gene segments determines an individual’s naïve Ig repertoire, and consequently (auto)antigen recognition. VDJ recombination follows probabilistic rules that can be modeled statistically. So far, it remains unknown whether VDJ recombination rules differ between individuals. If these rules differed, identical (auto)...

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Identifiers and source

Literature Corpus work: a991290d-da61-55da-900d-c30e109ef904
DOI: 10.1101/2021.04.19.440409

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