Article

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

2021-09-20

Abstract excerpt

Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual’s genetic background is associated with their resulting TCR repertoire diversity has yet to be fully explored. Using a...

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Literature Corpus work: 01a24f63-8480-5a7e-8644-0e9f163b237a
DOI: 10.1101/2021.09.17.460747

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