Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inferring processes underlying B-cell repertoire diversity

20 Jul 2015

Abstract excerpt

We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first after its initial generation via VDJ recombination and then after selection for functionality. We also infer statistical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26194757
DOI: 10.1098/rstb.2014.0243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inferring processes underlying B-cell repertoire diversityPMID 26194757Read ↗

Inferring processes underlying B-cell repertoire diversitySemantic proximity Read ↗

Combining mutation and recombination statistics to infer clonal families in antibody repertoiresSemantic proximity Read ↗

Combining mutation and recombination statistics to infer clonal families in antibody repertoires.Semantic proximity Read ↗

Individualized VDJ recombination predisposes the available Ig sequence spaceSemantic proximity Read ↗

Ancestra: A lineage-explicit simulator for benchmarking B-cell receptor repertoire and lineage inference methodsSemantic proximity Read ↗

Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.Semantic proximity Read ↗

Quantifying selection in immune receptor repertoiresSemantic proximity Read ↗

Quantifying lymphocyte receptor diversitySemantic proximity Read ↗

Quantifying selection in immune receptor repertoiresSemantic proximity Read ↗

Practical guidelines for B-cell receptor repertoire sequencing analysisSemantic proximity Read ↗

Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire dataSemantic proximity Read ↗

A Public Database of Memory and Naive B-Cell Receptor SequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.