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Article

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities.

eLife - 22 Mar 2022

Russell Magdalena L, Souquette Aisha, Levine David M, Schattgen Stefan A, Allen E Kaitlynn, Kuan Guillermina, Simon Noah, Balmaseda Angel, Gordon Aubree, Thomas Paul G, Matsen Frederick A, Bradley Philip

Abstract excerpt

Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual's genetic background is associated with their resulting TCR repertoire diversity has yet to be fully explored. Using a...

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Identifiers

PMID: 35315770
DOI: 10.7554/eLife.73475
PMCID: PMC8940181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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