Quantifying the Recoverability of V and J Genes from TCR CDR3 Sequences Using Generative Repertoire Models

Abstract excerpt

<h4>Introduction: </h4> How much of the variable (V) and joining (J) gene identity of a T-cell receptor is recoverable from its third complementarity-determining region (CDR3) amino-acid sequence alone? Immune repertoire studies often report the CDR3 with V and J annotation that is missing, low-confidence, or inconsistent, so what the CDR3 alone can and cannot fix is both a basic question about the receptor and a...

Topics

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• Algorithms
• Antibody Diversity
• High-Throughput Nucleotide Sequencing
• Immune Cell Function and Interaction
• Immunoglobulin Variable Region
• Receptors, Antigen, T-Cell
• T-cell and B-cell Immunology
• T-Lymphocytes

Identifiers and source

Literature Corpus work

3543fdbf-55ac-566f-be66-42b56cb8dde4

DOI

10.64898/2026.08.24.746073