Article

Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals

2023-07-28

Abstract excerpt

The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acquired and selected during T cell maturation in the thymus. Characterizing TCR repertoires across individuals and T cell maturation stages is important for better understanding adaptive immune responses and for developing new diagnostics...

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Identifiers and source

Literature Corpus work: 0857ea93-e771-569b-a853-d11804e6ee64
DOI: 10.1101/2023.07.25.550534

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