Article

Statistical analysis of repertoire data demonstrates the influence of microhomology in V(D)J recombination

2024-10-18

Abstract excerpt

V(D)J recombination generates the diverse B and T cell receptors essential for recognizing a wide array of antigens. This diversity arises from the combinatorial assembly of V(D)J genes and the junctional deletion and insertion of nucleotides. While previous in vitro studies have shown that microhomology—–short stretches of sequence homology between gene ends—–can bias the recombination process, the extent of mic...

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Literature Corpus work: 179ad0ab-8f62-5f65-9ac6-7a150f2fee47
DOI: 10.1101/2024.10.16.618753

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