Article

Inferring processes underlying B-cell repertoire diversity

2015-02-11

Abstract excerpt

We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first after its initial generation via VDJ recombination and then after selection for functionality. We also infer statistical properti...

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Literature Corpus work: 2c4970d3-fe3b-56f8-8336-d0e9ca0d7192
DOI: 10.1101/015115

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