Article

Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

2022-01-06

Abstract excerpt

Centromeres are specialized chromosome loci that seed the kinetochore, a large protein complex that effects chromosome segregation. The organization of the interface between the kinetochore and the specialized centromeric chromatin, marked by the histone H3 variant CENP-A, remains incompletely understood. A 16-subunit complex, the constitutive centromere associated network (CCAN), bridges CENP-A to the spindle-bin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9772563-69d6-5de6-bc54-190431c22a5d
DOI: 10.1101/2022.01.06.475204

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure of the human inner kinetochore CCAN complex and its significance for human centromere organizationDOI 10.1101/2022.01.06.475204Read

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosomeSemantic proximity Read

Assembly principles and stoichiometry of a complete human kinetochore moduleSemantic proximity Read

CENP-A and CENP-B collaborate to create an open centromeric chromatin stateSemantic proximity Read

CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.Semantic proximity Read

Stepwise unfolding supports a subunit model for vertebrate kinetochores.Semantic proximity Read

The ratio between centromeric proteins CENP-A and CENP-C maintains homeostasis of human centromeresSemantic proximity Read

The pseudo GTPase CENP-M drives human kinetochore assembly.Semantic proximity Read

Structure of the human outer kinetochore KMN network complexSemantic proximity Read

Defining a core configuration for human centromeres during mitosisSemantic proximity Read

CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization.Semantic proximity Read

In vivo functional dissection of human inner kinetochore protein CENP-C.Semantic proximity Read

Computer-aided molecular modeling and structural analysis of the human centromere protein-HIKM complexSemantic proximity Read