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Article

CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization.

The Journal of cell biology - 2 Dec 2019

Watanabe Reito, Hara Masatoshi, Okumura Ei-Ichi, Hervé Solène, Fachinetti Daniele, Ariyoshi Mariko, Fukagawa Tatsuo

Abstract excerpt

The kinetochore is essential for faithful chromosome segregation during mitosis. To form a functional kinetochore, constitutive centromere-associated network (CCAN) proteins are assembled on the centromere chromatin that contains the centromere-specific histone CENP-A. CENP-C, a CCAN protein, directly interacts with the CENP-A nucleosome to nucleate the kinetochore structure. As CENP-C is a hub protein for...

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Identifiers

PMID: 31676716
DOI: 10.1083/jcb.201907006
PMCID: PMC6891089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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