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Structure of the human outer kinetochore KMN network complex

8 Mar 2024

Abstract excerpt

Faithful chromosome segregation requires robust, load-bearing attachments of chromosomes to the mitotic spindle, a function accomplished by large macromolecular complexes termed kinetochores. In most eukaryotes, the constitutive centromere-associated network (CCAN) complex of the inner kinetochore recruits to centromeres the ten-subunit outer kinetochore KMN network that comprises the KNL1C, MIS12C and NDC80C...

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PMID: 38459127
DOI: 10.1038/s41594-024-01249-y

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