Article

Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

2022-01-08

Abstract excerpt

Accurate chromosome segregation, controlled by kinetochore-mediated chromatid attachments to the mitotic spindle, ensures the faithful inheritance of genetic information. Kinetochores assemble onto specialized CENP-A nucleosomes (CENP-A Nuc ) of centromeric chromatin. In humans, this is mostly organized as thousands of copies of an ∼171 bp α -satellite repeat. Here, we describe the cryo-EM structure of the human...

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Literature Corpus work: 74711a87-2d41-59de-aaae-196fd06aa51e
DOI: 10.1101/2022.01.07.475394

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