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Article

Stepwise unfolding supports a subunit model for vertebrate kinetochores.

Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2017

Vargiu Giulia, Makarov Alexandr A, Allan James, Fukagawa Tatsuo, Booth Daniel G, Earnshaw William C

Abstract excerpt

During cell division, interactions between microtubules and chromosomes are mediated by the kinetochore, a proteinaceous structure located at the primary constriction of chromosomes. In addition to the centromere histone centromere protein A (CENP-A), 15 other members of the constitutive centromere associated network (CCAN) participate in the formation of a chromatin-associated scaffold that supports kinetochore...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28265097
DOI: 10.1073/pnas.1614145114
PMCID: PMC5373359

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Stepwise unfolding supports a subunit model for vertebrate kinetochores.PMID 28265097Read ↗

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CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.Semantic proximity Read ↗

Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.Semantic proximity Read ↗

Defining a core configuration for human centromeres during mitosisSemantic proximity Read ↗

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