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Article

The pseudo GTPase CENP-M drives human kinetochore assembly.

eLife - 8 Jul 2014

Basilico Federica, Maffini Stefano, Weir John R, Prumbaum Daniel, Rojas Ana M, Zimniak Tomasz, De Antoni Anna, Jeganathan Sadasivam, Voss Beate, van Gerwen Suzan, Krenn Veronica, Massimiliano Lucia, Valencia Alfonso, Vetter Ingrid R, Herzog Franz, Raunser Stefan, Pasqualato Sebastiano, Musacchio Andrea

Abstract excerpt

Kinetochores, multi-subunit complexes that assemble at the interface with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes during cell division. The configuration and function of the kinetochore-centromere interface is poorly understood. We report that a protein at this interface, CENP-M, is structurally and evolutionarily related to small GTPases but is incapable of GTP-binding...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25006165
DOI: 10.7554/eLife.02978
PMCID: PMC4080450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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